Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180558 | 0.84 | DGAT1 (0.56) | DGAT1SOAT2SOAT1 | |
| SCHEMBL180942 | 0.84 | DGAT1 (0.62) | DGAT1SOAT2SOAT1 | |
| SCHEMBL180908 | 0.82 | DGAT1 (0.57) | DGAT1SOAT2SOAT1 | |
| SCHEMBL180779 | 0.81 | DGAT1 (0.58) | DGAT1RAB9ASOAT2SOAT1 | |
| SCHEMBL180618 | 0.81 | DGAT1 (0.67) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL180995 | 0.80 | DGAT1 (0.61) | DGAT1SOAT2 | |
| SCHEMBL181043 | 0.80 | DGAT1 (0.60) | DGAT1ALDH1A1RAB9ASOAT1 | |
| SCHEMBL180682 | 0.79 | DGAT1 (0.53) | DGAT1SOAT2SOAT1 | |
| SCHEMBL14617033 | 0.78 | DGAT1 (0.66) | DGAT1SOAT1 | |
| SCHEMBL180687 | 0.78 | DGAT1 (0.66) | DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004607-A2 | NEW COMPOUNDS | Novartis AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007126957-A2 | NEW COMPOUNDS | NOVARTIS AG (CH) | 2007-11-08 | — | — | WO | disclosed |