Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.51 |
| ▸ | BAD | Q92934 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | SENP5 | Q96HI0 | 2/20 | 0.46 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605365 | 0.89 | LMNA (0.56) | CXCR2MCL1BCL2BCL2L1BAD | |
| SCHEMBL1381986 | 0.85 | MAPT (0.69) | CXCR2MCL1BCL2BCL2L1BAD | |
| SCHEMBL4635087 | 0.85 | MCL1 (0.70) | CXCR2MCL1BCL2BCL2L1BAD | |
| SCHEMBL4634438 | 0.84 | MCL1 (0.54) | CXCR2MCL1BCL2BCL2L1BAD | |
| SCHEMBL9024044 | 0.82 | CXCR2 (0.54) | CXCR2MCL1BCL2BCL2L1BAD | |
| SCHEMBL4633866 | 0.82 | CXCR2 (0.67) | CXCR2MCL1BCL2BCL2L1BAD | |
| SCHEMBL4633954 | 0.81 | MAPT (0.55) | CXCR2MCL1BCL2BCL2L1BAD | |
| SCHEMBL1098130 | 0.80 | MCL1 (0.57) | CXCR2MCL1LMNAMAPTL3MBTL1 | |
| SCHEMBL25274266 | 0.80 | PTPN2 (0.53) | CXCR2MCL1BCL2BCL2L1BAD | |
| SCHEMBL4635058 | 0.80 | CXCR2 (0.58) | CXCR2MCL1BCL2BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685121-B1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | claimed |