Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | MAX | P61244 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134648 | 0.99 | EGFR (0.43) | EGFRERBB2ALOX5ALDH1A1KDM4E | |
| SCHEMBL4277628 | 0.91 | BCL2 (0.48) | EGFRERBB2ALOX5BCL2BCL2L1 | |
| SCHEMBL4277634 | 0.91 | BCL2 (0.48) | EGFRERBB2ALOX5BCL2BCL2L1 | |
| SCHEMBL4128622 | 0.90 | EGFR (0.56) | EGFRERBB2ALOX5ALDH1A1TSHR | |
| SCHEMBL4128620 | 0.90 | EGFR (0.56) | EGFRERBB2ALOX5ALDH1A1TSHR | |
| SCHEMBL4125381 | 0.90 | BCL2 (0.49) | EGFRERBB2ALOX5BCL2BCL2L1 | |
| SCHEMBL4794860 | 0.90 | ALOX5 (0.48) | EGFRERBB2ALOX5BCL2BCL2L1 | |
| SCHEMBL4125379 | 0.90 | BCL2 (0.49) | EGFRERBB2ALOX5BCL2BCL2L1 | |
| SCHEMBL4124023 | 0.90 | ALOX5 (0.48) | EGFRERBB2ALOX5BCL2BCL2L1 | |
| SCHEMBL4137539 | 0.89 | ALOX5 (0.52) | EGFRERBB2ALOX5MAPTBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | disclosed |