Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4634758 | 1.00 | ALOX5 (0.52) | ALOX5FABP4NR1H4PDE4BPTGER4 | |
| SCHEMBL4128997 | 0.85 | ALOX5 (0.40) | ALOX5FABP4NR1H4PDE4BPTGER4 | |
| SCHEMBL4128994 | 0.85 | ALOX5 (0.40) | ALOX5FABP4NR1H4PDE4BPTGER4 | |
| SCHEMBL4122284 | 0.84 | PDE4B (0.42) | ALOX5FABP4NR1H4PDE4BPDE4D | |
| SCHEMBL4122280 | 0.84 | PDE4B (0.42) | ALOX5FABP4NR1H4PDE4BPDE4D | |
| SCHEMBL4127737 | 0.80 | KMT2A (0.49) | ALOX5MEN1KMT2ATDP1MAPT | |
| SCHEMBL4127729 | 0.80 | KMT2A (0.49) | ALOX5MEN1KMT2ATDP1MAPT | |
| SCHEMBL4131441 | 0.80 | KMT2A (0.51) | ALOX5MEN1KMT2ATDP1MAPT | |
| SCHEMBL4136345 | 0.80 | KMT2A (0.51) | ALOX5MEN1KMT2ATDP1MAPT | |
| SCHEMBL4133860 | 0.79 | DUSP22 (0.49) | ALOX5PDE4BALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | claimed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | claimed |
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | disclosed |