Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635765 | 0.93 | GRM5 (0.44) | GRM5MAOAMAOB | |
| SCHEMBL4329069 | 0.82 | GRM5 (0.44) | GRM5MAOAMAOB | |
| SCHEMBL4337979 | 0.78 | GRM5 (0.60) | GRM5 | |
| SCHEMBL4635784 | 0.77 | GRM5 (0.37) | GRM5 | |
| SCHEMBL4340468 | 0.76 | CYP2C19 (0.49) | GRM5MAOAMAOB | |
| SCHEMBL4338024 | 0.76 | CYP2C19 (0.49) | GRM5MAOAMAOB | |
| SCHEMBL4635582 | 0.76 | GRM5 (0.36) | GRM5MAOB | |
| SCHEMBL4635775 | 0.74 | GRM5 (0.33) | GRM5 | |
| SCHEMBL4328414 | 0.73 | GRM5 (0.58) | GRM5 | |
| SCHEMBL4338033 | 0.73 | GRM5 (0.58) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931635-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007023290-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |