Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4634810 | 0.93 | GRM5 (0.38) | GRM5MAOAMAOB | |
| SCHEMBL4329069 | 0.88 | GRM5 (0.44) | GRM5MAOAMAOBCYP2C19ALDH1A1 | |
| SCHEMBL4337979 | 0.84 | GRM5 (0.60) | GRM5MAPT | |
| SCHEMBL4340468 | 0.82 | CYP2C19 (0.49) | GRM5MAOAMAOBCYP2C19ALDH1A1 | |
| SCHEMBL4328414 | 0.78 | GRM5 (0.58) | GRM5 | |
| SCHEMBL4340475 | 0.74 | GRM5 (0.64) | GRM5 | |
| SCHEMBL4634801 | 0.74 | GRM5 (0.56) | GRM5MAOAMAOBCYP2C19ALDH1A1 | |
| SCHEMBL4635073 | 0.73 | GRM5 (0.42) | GRM5 | |
| SCHEMBL4635243 | 0.70 | GRM5 (0.41) | GRM5MAOAMAOBCYP2C19ALDH1A1 | |
| SCHEMBL13707074 | 0.69 | CYP2C19 (0.47) | GRM5MAOAMAOBCYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931635-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-06-18 | — | — | EP | claimed |
| WO-2007023290-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | claimed |