Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.44 |
| ▸ | GABRE | P78334 | 2/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.44 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211251 | 0.84 | NPC1 (0.46) | NPC1RAB9AKMT2AGABRPGABRD | |
| SCHEMBL23507861 | 0.83 | NPC1 (0.44) | NPC1RAB9AKMT2AGABRPGABRD | |
| SCHEMBL31554152 | 0.81 | POLB (0.47) | NPC1RAB9AKMT2AGABRPGABRD | |
| SCHEMBL31172721 | 0.81 | TUBB4A (0.49) | NPC1RAB9AKMT2AGABRPGABRD | |
| SCHEMBL24718011 | 0.81 | NPC1 (0.43) | NPC1RAB9AKMT2AGABRPGABRD | |
| SCHEMBL25571855 | 0.81 | TUBB4A (0.49) | NPC1RAB9AKMT2AGABRPGABRD | |
| SCHEMBL18572898 | 0.81 | NPC1 (0.43) | NPC1RAB9AKMT2AGABRPGABRD | |
| SCHEMBL4184724 | 0.78 | NPC1 (0.51) | NPC1RAB9AKMT2AGABRPGABRD | |
| SCHEMBL4472256 | 0.78 | TUBB4A (0.51) | NPC1RAB9AKMT2AGABRPGABRD | |
| SCHEMBL4737223 | 0.77 | SMN1; SMN2 (0.55) | NPC1RAB9ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934182-A1 | N-SUBSTITUTED PYRIDINONE OR PYRIMIDINONE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007044491-A1 | N-SUBSTITUTED PYRIDINONE OR PYRIMIDINONE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-04-19 | — | — | WO | disclosed |