Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635253 | 1.00 | EGFR (0.48) | EGFRERBB2ALOX5KMT2APOLB | |
| SCHEMBL4635258 | 0.99 | EGFR (0.48) | EGFRERBB2ALOX5KMT2APOLB | |
| SCHEMBL4634394 | 0.93 | EGFR (0.42) | EGFRERBB2KMT2ALMNAMAPT | |
| SCHEMBL4634397 | 0.93 | EGFR (0.42) | EGFRERBB2KMT2ALMNAMAPT | |
| SCHEMBL4634400 | 0.92 | EGFR (0.43) | EGFRERBB2KMT2ALMNAMAPT | |
| SCHEMBL4133774 | 0.91 | EGFR (0.41) | EGFRERBB2KMT2ALMNAMAPT | |
| SCHEMBL4133773 | 0.91 | EGFR (0.41) | EGFRERBB2KMT2ALMNAMAPT | |
| SCHEMBL4128340 | 0.90 | EGFR (0.42) | EGFRERBB2KMT2ALMNAMAPT | |
| SCHEMBL4128343 | 0.90 | EGFR (0.42) | EGFRERBB2KMT2ALMNAMAPT | |
| SCHEMBL4133775 | 0.90 | EGFR (0.42) | EGFRERBB2KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | claimed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | claimed |
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | disclosed |