Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 8/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635505 | 0.90 | BTK (0.41) | MAP4K4BTKJAK3DPP4LCK | |
| SCHEMBL4635245 | 0.89 | BTK (0.41) | MAP4K4BTKJAK3DPP4LCK | |
| SCHEMBL4636249 | 0.88 | JAK3 (0.42) | MAP4K4BTKJAK3DPP4LCK | |
| SCHEMBL556164 | 0.87 | MAP4K4 (0.46) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL5437210 | 0.87 | MAP4K4 (0.46) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL4634913 | 0.84 | MAP4K4 (0.47) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL3971382 | 0.81 | BTK (0.41) | MAP4K4BTKJAK3DPP4LCK | |
| SCHEMBL5435581 | 0.81 | BTK (0.42) | MAP4K4BTKJAK3DPP4LCK | |
| SCHEMBL3967464 | 0.79 | DPP4 (0.42) | MAP4K4BTKJAK3DPP4LCK | |
| SCHEMBL556256 | 0.79 | BTK (0.41) | MAP4K4BTKJAK3DPP4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532150-B1 | NOVEL PURINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-06-11 | — | — | EP | disclosed |