Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 9/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636249 | 0.92 | JAK3 (0.42) | BTKJAK3MAP4K4DPP4LCK | |
| SCHEMBL4635283 | 0.90 | MAP4K4 (0.44) | BTKJAK3MAP4K4DPP4LCK | |
| SCHEMBL4635245 | 0.88 | BTK (0.41) | BTKJAK3MAP4K4DPP4LCK | |
| SCHEMBL3971382 | 0.88 | BTK (0.41) | BTKJAK3MAP4K4DPP4LCK | |
| SCHEMBL556256 | 0.83 | BTK (0.41) | BTKJAK3MAP4K4DPP4LCK | |
| SCHEMBL554830 | 0.81 | BTK (0.40) | BTKJAK3MAP4K4DPP4LCK | |
| SCHEMBL3977507 | 0.81 | BTK (0.43) | BTKJAK3MAP4K4DPP4LCK | |
| SCHEMBL556933 | 0.81 | BTK (0.40) | BTKJAK3MAP4K4DPP4LCK | |
| SCHEMBL556491 | 0.81 | BTK (0.40) | BTKJAK3MAP4K4DPP4LCK | |
| SCHEMBL5437210 | 0.80 | MAP4K4 (0.46) | BTKJAK3MAP4K4DPP4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532150-B1 | NOVEL PURINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1532150-A1 | NOVEL PURINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004018469-A1 | NOVEL PURINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | WO | disclosed |