Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245105 | 1.00 | CYP2C19 (0.43) | CYP2C19MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL245950 | 1.00 | CYP2C19 (0.43) | CYP2C19MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13072762 | 0.84 | CYP2C19 (0.42) | CYP2C19MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15492137 | 0.84 | CYP2C19 (0.42) | CYP2C19MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15214943 | 0.84 | CYP2C19 (0.42) | CYP2C19MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7760225 | 0.78 | CYP2C19 (0.46) | CYP2C19MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4613844 | 0.78 | SMN1; SMN2 (0.37) | CYP2C19SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL4614582 | 0.78 | SMN1; SMN2 (0.37) | CYP2C19SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL4612566 | 0.78 | SMN1; SMN2 (0.37) | CYP2C19SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL11129656 | 0.75 | MEN1 (0.46) | CYP2C19MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976381-A2 | TRI-SUBSTITUTED 2-BENZHYDRYL-5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES | WAYNE STATE UNIVERSITY (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007082292-A2 | TRI-SUBSTITUTED 2-BENZHYDRYL-5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES | WAYNE STATE UNIVERSITY (US) | 2007-07-19 | — | — | WO | disclosed |