Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Trehalose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF2R | P11717 | 3/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GJA1 | P17302 | 1/20 | 0.48 |
| ▸ | GJB2 | P29033 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SYNJ2 | O15056 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trehalose SCHEMBL20111150 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 | |
| SCHEMBL17154856 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 | |
| SCHEMBL5357747 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 | |
| Trehalose SCHEMBL23029503 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 | |
| Trehalose SCHEMBL12694649 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 | |
| Trehalose SCHEMBL25304700 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 | |
| Trehalose SCHEMBL732715 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 | |
| SCHEMBL18197649 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 | |
| Trehalose SCHEMBL19576005 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 | |
| Trehalose SCHEMBL4257808 | 0.85 | MEN1 (0.57) | PTPN1MEN1KMT2AGJA1GJB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018096460-A1 | PHARMACEUTICAL COMPOSITIONS OF GLP-1 ANALOGUES | BIOCON RESEARCH LIMITED (IN) | 2018-05-31 | — | — | WO | disclosed |
| EP-1931306-A1 | NON-PROTEIN STABILIZED CLOSTRIDIAL TOXIN PHARMACEUTICAL COMPOSITIONS | Allergan, Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007041664-A1 | NON-PROTEIN STABILIZED CLOSTRIDIAL TOXIN PHARMACEUTICAL COMPOSITIONS | ALLERGAN, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2005089503-A2 | CD4-IGG2 FORMULATIONS | PROGENICS PHARMACEUTICALS, INC. (US) | 2005-09-29 | — | — | WO | disclosed |
| WO-2004084816-A2 | IMPROVED CD4-IgG2 FORMULATIONS | PROGENICS PHARMACEUTICALS, INC. (US) | 2004-10-07 | — | — | WO | disclosed |