Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6128307 | 0.82 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL189700 | 0.80 | ALDH1A1 (0.57) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1898472 | 0.69 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL12676203 | 0.69 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL12676338 | 0.68 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL4231600 | 0.68 | ADORA1 (0.46) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL13895692 | 0.68 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL15104473 | 0.67 | PIK3CA (0.45) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL189326 | 0.67 | ALDH1A1 (0.65) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL189165 | 0.66 | FGFR1 (0.51) | PIK3CAPIK3CDPIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940839-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kalpha | Exelixis, Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007044813-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | claimed |