Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.82 |
| ▸ | KDR | P35968 | 20/20 | 0.82 |
| ▸ | MST1R | Q04912 | 2/20 | 0.82 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | FPR1 | P21462 | 1/20 | 0.55 |
| ▸ | FPR3 | P25089 | 1/20 | 0.55 |
| ▸ | GPR183 | P32249 | 1/20 | 0.55 |
| ▸ | SMO | Q99835 | 1/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306370 | 0.90 | MET (1.00) | METKDRMST1RAURKAFPR1 | |
| SCHEMBL896429 | 0.89 | MET (0.85) | METKDRMST1R | |
| SCHEMBL308057 | 0.88 | MET (1.00) | METKDRMST1RAURKAFPR1 | |
| SCHEMBL14262902 | 0.86 | MET (0.94) | METKDRMST1RAURKAFPR1 | |
| SCHEMBL896301 | 0.84 | MET (0.80) | METKDRMST1R | |
| SCHEMBL898268 | 0.83 | MET (1.00) | METKDRMST1RAURKAFPR1 | |
| SCHEMBL898112 | 0.81 | MET (1.00) | METKDRMST1RAURKAFPR1 | |
| SCHEMBL307958 | 0.80 | MET (0.84) | METKDRMST1RAURKAFPR1 | |
| SCHEMBL10288994 | 0.80 | MET (0.81) | METKDRMST1RAURKAFPR1 | |
| SCHEMBL306290 | 0.78 | MET (1.00) | METKDRMST1RAURKAFPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957498-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | MethylGene Inc. (CA) | 2008-08-20 | — | — | EP | disclosed |
| WO-2008041053-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2008-04-10 | — | — | WO | disclosed |