Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2988958 | 0.99 | PDE4A (0.63) | PDE4APDE4BPDE4DPDE4CPOLB | |
| Hydrochloric Acid SCHEMBL4638650 | 0.98 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL5905200 | 0.95 | PDE4A (0.57) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL2993027 | 0.94 | PDE4A (0.58) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL4637671 | 0.89 | PDE4A (0.61) | PDE4APDE4BPDE4DPDE4CHIF1A | |
| SCHEMBL4637237 | 0.89 | PDE4A (0.52) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL2995451 | 0.88 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL5905136 | 0.88 | PDE4A (0.49) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL5905071 | 0.86 | PDE4A (0.50) | PDE4APDE4BPDE4DPDE4CPOLB | |
| Hydrochloric Acid SCHEMBL21494460 | 0.85 | PDE4A (0.49) | PDE4APDE4BPDE4DPDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0874819-B1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| US-5728844-A | INHIBITORS OF TUMOR NECROSIS AND PHOSPHODIESTERASE | CELGENE CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |