Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637671 | 0.99 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2985100 | 0.95 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL5905440 | 0.94 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2988958 | 0.89 | PDE4A (0.63) | PDE4APDE4DPDE4BPDE4CMAPK14 | |
| SCHEMBL4637687 | 0.88 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL4638650 | 0.88 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CMAPK14 | |
| SCHEMBL4637255 | 0.88 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CMAPK14 | |
| SCHEMBL3181116 | 0.88 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL5905386 | 0.86 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL4728355 | 0.85 | PDE4B (0.56) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083011-B1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2014-06-04 | — | — | EP | disclosed |
| US-8466191-B2 | Pyrroline derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof | ZHANG HESHENG (CN) | 2013-06-18 | — | — | US | disclosed |
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | ZHANG HESHENG | 2010-07-15 | — | — | US | disclosed |
| EP-2083011-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2009-07-29 | — | — | EP | disclosed |
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| US-20060264477-A1 | Methods of using cyclic amides | MULLER GEORGE W | 2006-11-23 | — | — | US | disclosed |
| US-7091356-B2 | Substituted alkanohydroxamic acids and method of reducing TNFα levels | CELGENE CORPORATION | 2006-08-15 | — | — | US | disclosed |
| US-7081464-B2 | Topical compositions of cyclic amides as immunotherapeutic agents | CELGENE CORPORATION (US) | 2006-07-25 | — | — | US | disclosed |
| US-20060003979-A1 | Topical compositions of cyclic amides as immunotherapeutic agents | CELGENE CORPORATION | 2006-01-05 | — | — | US | disclosed |
| US-20050096355-A1 | Novel immunotherapeutic agents | MULLER GEORGE W (US) | 2005-05-05 | — | — | US | disclosed |
| US-6180644-B1 | TUMOR NECROSIS FACTOR INHIBITOR; ANTIINFLAMMATORY AGENT | CELGENE CORPORATION | 2001-01-30 | — | — | US | disclosed |
| EP-1035848-A1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNF-ALPHA LEVELS | CELGENE CORPORATION (US) | 2000-09-20 | — | — | EP | disclosed |
| US-5968945-A | Immunotherapeutic agents | CELGENE CORPORATION (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0942902-A2 | NOVEL IMMUNOTHERAPEUTIC IMIDES/AMIDES | CELGENE CORPORATION (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1999006041-A1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNFα LEVELS | CELGENE CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |
| EP-0874819-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1998024763-A2 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AS PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-06-11 | — | — | WO | disclosed |
| US-5728844-A | INHIBITORS OF TUMOR NECROSIS AND PHOSPHODIESTERASE | CELGENE CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |
| US-5703098-A | INHIBITORS OF CYTOKINES INCLUDING TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |
| WO-1997023457-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096355-A1 | Novel immunotherapeutic agents | STING1, RNASE1, CGAS | PDE4A 8/4885PDE4D 38/4885PDE4B 15/4885 |
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TNF, IL1B, NOS1 | PDE4A 2306/4885PDE4D 3630/4885PDE4B 2498/4885 |
| US-20060003979-A1 | Topical compositions of cyclic amides as immunotherapeutic agents | TSLP, STING1, CGAS | PDE4A 8/4885PDE4D 30/4885PDE4B 21/4885 |
| US-20060264477-A1 | Methods of using cyclic amides | RNASE1, RNGTT, CGAS | PDE4A 5/4885PDE4D 35/4885PDE4B 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.