⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10515564 | 0.86 | MAPT (0.31) | — | |
| SCHEMBL12500834 | 0.79 | APAF1 (0.35) | — | |
| SCHEMBL18766357 | 0.77 | MAPT (0.34) | — | |
| SCHEMBL6129247 | 0.77 | MAPT (0.38) | — | |
| SCHEMBL11579318 | 0.76 | MAPT (0.37) | — | |
| SCHEMBL1821124 | 0.71 | MAPT (0.42) | — | |
| SCHEMBL31610423 | 0.67 | MEN1 (0.32) | — | |
| SCHEMBL31667754 | 0.67 | — | — | |
| SCHEMBL4275705 | 0.63 | MAPT (0.34) | — | |
| SCHEMBL7318007 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262070-A1 | Pharmaceutically Active Tetrahydro-Pyrrolizinone Compounds | BAUMANN KARL | 2008-10-23 | — | — | US | disclosed |
| US-20080262070-A1 | Pharmaceutically Active Tetrahydro-Pyrrolizinone Compounds | BAUMANN KARL | 2008-10-23 | — | — | US | disclosed |
| US-20080262070-A1 | Pharmaceutically Active Tetrahydro-Pyrrolizinone Compounds | BAUMANN KARL | 2008-10-23 | — | — | US | disclosed |
| CN-101277961-A | Tetrahydropyrrolizinone compounds as LFA-1 modulators | NOVARTIS AG (CH) | 2008-10-01 | — | — | CN | disclosed |
| CN-101277961-A | Tetrahydropyrrolizinone compounds as LFA-1 modulators | NOVARTIS AG (CH) | 2008-10-01 | — | — | CN | disclosed |
| CN-101277961-A | Tetrahydropyrrolizinone compounds as LFA-1 modulators | NOVARTIS AG (CH) | 2008-10-01 | — | — | CN | disclosed |
| EP-1937685-A1 | TETRAHYDRO-PYRROLIZINONE COMPOUNDS AS LFA-I MEDIATORS | Novartis AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| EP-1937685-A1 | TETRAHYDRO-PYRROLIZINONE COMPOUNDS AS LFA-I MEDIATORS | Novartis AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039286-A1 | TETRAHYDRO-PYRROLIZINONE COMPOUNDS AS LFA-I MEDIATORS | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007039286-A1 | TETRAHYDRO-PYRROLIZINONE COMPOUNDS AS LFA-I MEDIATORS | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | disclosed |