Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726020 | 0.88 | PTGDR2 (0.41) | SCN9AEPAS1PTGDR2TSHRHSD17B10 | |
| SCHEMBL4637590 | 0.84 | PTGDR2 (0.46) | EPAS1PTGDR2 | |
| SCHEMBL4637470 | 0.83 | SCN9A (0.39) | SCN9AEPAS1CYP1A2 | |
| SCHEMBL2065216 | 0.81 | PTGDR2 (0.49) | EPAS1PTGDR2 | |
| SCHEMBL4637444 | 0.79 | EPAS1 (0.53) | EPAS1PTGDR2 | |
| SCHEMBL1650552 | 0.74 | EPAS1 (0.37) | SCN9AEPAS1PTGDR2 | |
| SCHEMBL4205946 | 0.74 | TSHR (0.53) | TSHRHSD17B10ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL883829 | 0.74 | PTGDR2 (0.51) | SCN9AEPAS1PTGDR2 | |
| SCHEMBL10121181 | 0.73 | PTGDR2 (0.46) | EPAS1PTGDR2 | |
| SCHEMBL885402 | 0.73 | PTGDR2 (0.44) | EPAS1PTGDR2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |