Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 9/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639087 | 0.87 | EPAS1 (0.44) | PTGDR2EPAS1SOS1 | |
| SCHEMBL4637444 | 0.87 | EPAS1 (0.53) | PTGDR2EPAS1BRD4PTGS1PTGS2 | |
| SCHEMBL4637581 | 0.84 | SCN9A (0.41) | PTGDR2EPAS1 | |
| SCHEMBL4639089 | 0.82 | EPAS1 (0.55) | EPAS1VEGFA | |
| SCHEMBL4637470 | 0.81 | SCN9A (0.39) | EPAS1VEGFA | |
| SCHEMBL4637399 | 0.81 | EPAS1 (0.47) | PTGDR2EPAS1BRD4SOS1VEGFA | |
| SCHEMBL4637426 | 0.79 | PTGDR2 (0.42) | PTGDR2EPAS1BRD4 | |
| SCHEMBL4637496 | 0.77 | PTGDR2 (0.40) | PTGDR2EPAS1PTGS1PTGS2 | |
| SCHEMBL2066732 | 0.76 | PTGDR2 (0.53) | PTGDR2EPAS1 | |
| SCHEMBL4638008 | 0.76 | PTGDR2 (0.41) | PTGDR2EPAS1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |