Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PPARD | Q03181 | 5/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334527 | 0.81 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL17102006 | 0.79 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL4320695 | 0.78 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL333933 | 0.77 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2MAPTPPARD | |
| SCHEMBL334847 | 0.73 | PPARD (0.60) | NPC1RAB9ASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL334427 | 0.73 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2MAPTPPARD | |
| SCHEMBL27727271 | 0.72 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL13281549 | 0.71 | RAB9A (0.56) | NPC1RAB9AMAPTGAA | |
| SCHEMBL14046555 | 0.71 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL24329835 | 0.71 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101296914-A | Derivatives with PPAR agonist activity | SHIONOGI & CO (JP) | 2008-10-29 | — | — | CN | disclosed |
| EP-1939189-A1 | DERIVATIVE HAVING PPAR AGONISTIC ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2008-07-02 | — | — | EP | disclosed |