Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 15/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8389316 | 0.89 | MAPK14 (0.64) | PTGS2PTGS1MAPK14 | |
| Sulfamide SCHEMBL4639068 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL214185 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8871716 | 0.81 | PTGS2 (0.63) | PTGS2PTGS1MAPK14 | |
| SCHEMBL8653562 | 0.80 | PTGS2 (0.72) | PTGS2PTGS1 | |
| Sulfamide SCHEMBL4638292 | 0.78 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL6730086 | 0.78 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL6739430 | 0.77 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL6737348 | 0.77 | PTGS2 (0.67) | PTGS2PTGS1MAPK14 | |
| SCHEMBL6725681 | 0.76 | PTGS2 (0.65) | PTGS2PTGS1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479385-B1 | Use of cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia | SEARLE LLC (US) | 2008-07-02 | — | — | EP | claimed |