SCHEMBL4638522

SCHEMBL4638522

CON(C)C(=O)c1nnn(Cc2cc(Cl)cc(Cl)c2)c1-c1ccncc1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 8/20 0.44
ALDH1A1 P00352 1/20 0.38
TSHR P16473 1/20 0.38
POLB P06746 1/20 0.38
NR1I3 Q14994 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
CYP1A2 P05177 1/20 0.35
SLC16A3 O15427 1/20 0.34
P2RX7 Q99572 1/20 0.34
GALR3 O60755 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
NR2F2 P24468 1/20 0.34
HIF1A Q16665 1/20 0.34
GRN P28799 1/20 0.33
SORT1 Q99523 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4639434 0.88 CYP19A1 (0.42) CYP19A1ALDH1A1TSHRNR1I3SMN1; SMN2
SCHEMBL4638527 0.85 USP2 (0.41) CYP19A1ALDH1A1TSHRPOLBSMN1; SMN2
SCHEMBL4639451 0.82 CYP19A1 (0.48) CYP19A1ALDH1A1TSHRPOLBSMN1; SMN2
SCHEMBL4637778 0.81 CYP19A1 (0.68) CYP19A1POLBSMN1; SMN2CYP1A2CYP2C9
SCHEMBL4638842 0.76 CYP19A1 (0.48) CYP19A1ALDH1A1TSHRPOLB
SCHEMBL4638983 0.75 IDH1 (0.49) CYP19A1ALDH1A1TSHRCYP3A4HIF1A
SCHEMBL4637975 0.75 CYP19A1 (0.39) CYP19A1ALDH1A1TSHRNR1I3P2RX7
SCHEMBL4637771 0.74 IDH1 (0.42) CYP19A1ALDH1A1
SCHEMBL4637971 0.73 CYP19A1 (0.50) CYP19A1ALDH1A1TSHRSMN1; SMN2CYP1A2
SCHEMBL4637737 0.73 HSP90AA1 (0.38) CYP19A1ALDH1A1TSHRSMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1501808-B1 TACHYKININ RECEPTOR ANTAGONISTS LILLY CO ELI (US) 2008-07-02 EP disclosed