Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637989 | 0.89 | ABL1 (0.47) | ABL1KDRCYP11B1CYP11B2NAMPT | |
| SCHEMBL4637852 | 0.81 | ABL1 (0.40) | ABL1KDRCYP11B1CYP11B2CHRM5 | |
| SCHEMBL4637939 | 0.80 | POLQ (0.42) | KDRCYP11B1CYP11B2ALDH1A1LMNA | |
| SCHEMBL4637771 | 0.79 | IDH1 (0.42) | KDRHCRTR1HCRTR2ALDH1A1MAPT | |
| SCHEMBL5795131 | 0.79 | ABL1 (0.43) | ABL1HCRTR1HCRTR2ALDH1A1LMNA | |
| SCHEMBL4638983 | 0.79 | IDH1 (0.49) | ALDH1A1 | |
| SCHEMBL4639523 | 0.77 | MAPT (0.46) | ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5794454 | 0.77 | CYP19A1 (0.49) | ABL1HCRTR1HCRTR2ALDH1A1MAPT | |
| SCHEMBL6426240 | 0.76 | ABL1 (0.38) | ABL1CYP11B1CYP11B2CHRM5MAPT | |
| SCHEMBL4637975 | 0.76 | CYP19A1 (0.39) | KDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |