Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 6/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637972 | 0.87 | ALDH1A1 (0.44) | ALDH1A1TSHRCYP19A1GAAGRM2 | |
| SCHEMBL4637790 | 0.86 | ALDH1A1 (0.43) | ALDH1A1TSHRCYP19A1GAAGRM2 | |
| SCHEMBL4639421 | 0.86 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP19A1GAAGRM2 | |
| SCHEMBL14587212 | 0.86 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP19A1GAAGRM2 | |
| SCHEMBL4709706 | 0.85 | ALDH1A1 (0.42) | ALDH1A1TSHRCYP19A1GAAGRM2 | |
| SCHEMBL4638499 | 0.85 | ALDH1A1 (0.40) | ALDH1A1TSHRCYP19A1PTGER4GAA | |
| SCHEMBL4706801 | 0.85 | ALDH1A1 (0.42) | ALDH1A1TSHRCYP19A1GAAGRM2 | |
| SCHEMBL4639386 | 0.84 | ALDH1A1 (0.40) | ALDH1A1TSHRCYP19A1PTGER4GAA | |
| SCHEMBL4637902 | 0.83 | ALDH1A1 (0.40) | ALDH1A1TSHRCYP19A1GAAGRM2 | |
| SCHEMBL4639476 | 0.82 | GPBAR1 (0.38) | ALDH1A1TSHRCYP19A1GAAGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |
| US-7179804-B2 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179804-B2 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179804-B2 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-02-20 | — | — | US | disclosed |
| US-20050239776-A1 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2005-10-27 | — | — | US | disclosed |
| EP-1501808-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091227-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239776-A1 | Tachykinin receptor antagonists | TACR2, TACR1, PROKR1 | ALDH1A1 1988/4885TSHR 337/4885CYP19A1 2765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.