Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 8/20 | 0.65 |
| ▸ | CA2 | P00918 | 8/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.63 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.63 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.63 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.63 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CA9 | Q16790 | 5/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13505527 | 0.79 | MAPT (0.56) | CA1CA2MEN1KMT2ACACNA1B | |
| SCHEMBL20726103 | 0.79 | MEN1 (0.60) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL20718860 | 0.79 | MEN1 (0.60) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL20718859 | 0.79 | MEN1 (0.60) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL8687081 | 0.79 | GAA (0.66) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL28801368 | 0.74 | CA1 (0.59) | CA1CA2CACNA1BAPBA1CA9 | |
| SCHEMBL21580603 | 0.73 | CA1 (0.67) | CA1CA2CACNA1BAPBA1CA9 | |
| SCHEMBL12703929 | 0.73 | CA1 (0.67) | CA1CA2CACNA1BAPBA1CA9 | |
| SCHEMBL21580604 | 0.73 | CA1 (0.67) | CA1CA2CACNA1BAPBA1CA9 | |
| SCHEMBL12670663 | 0.72 | NPC1 (0.54) | MEN1KMT2APOLBGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476149-B1 | SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2 | UNIV TEMPLE (US) | 2008-08-06 | — | — | EP | disclosed |
| US-7122571-B2 | Substituted hydrazones as inhibitors of cyclooxygenase-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-10-17 | — | — | US | disclosed |