Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 11/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.63 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213440 | 0.84 | PTGS2 (0.72) | PTGS1PTGS2CA1CA2CA9 | |
| Sulfamide SCHEMBL4639024 | 0.82 | PTGS2 (0.45) | PTGS1PTGS2CA1CA2CA9 | |
| SCHEMBL9117510 | 0.78 | PTGS2 (0.64) | PTGS1PTGS2CA1CA2CA9 | |
| SCHEMBL9116322 | 0.78 | PTGS2 (0.64) | PTGS1PTGS2CA1CA2CA9 | |
| SCHEMBL6913966 | 0.78 | PTGS2 (0.86) | PTGS1PTGS2 | |
| SCHEMBL213199 | 0.77 | PTGS2 (1.00) | PTGS1PTGS2 | |
| SCHEMBL9117806 | 0.77 | PTGS2 (0.55) | PTGS1PTGS2CA1CA2CA9 | |
| SCHEMBL9118460 | 0.75 | PTGS2 (0.74) | PTGS1PTGS2ALDH1A1 | |
| SCHEMBL9116386 | 0.75 | CA1 (0.41) | PTGS1PTGS2CA1CA2CA9 | |
| SCHEMBL9117796 | 0.74 | PTGS2 (0.58) | PTGS1PTGS2CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479385-B1 | Use of cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia | SEARLE LLC (US) | 2008-07-02 | — | — | EP | claimed |