Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 15/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243345 | 0.88 | ADORA2B (0.54) | ADORA2BADORA1ADORA2AKDM4EMEN1 | |
| SCHEMBL4176128 | 0.82 | ADORA2B (0.62) | ADORA2BADORA1ADORA2AKDM4EMEN1 | |
| SCHEMBL242409 | 0.80 | ADORA2B (0.56) | ADORA2BADORA1ADORA2AKDM4EMEN1 | |
| SCHEMBL1947253 | 0.80 | ADORA2B (0.61) | ADORA2BADORA1ADORA2AKDM4EMEN1 | |
| SCHEMBL4291542 | 0.80 | ADORA2B (0.66) | ADORA2BADORA1ADORA2AKDM4EMEN1 | |
| SCHEMBL5687959 | 0.78 | ADORA2B (0.63) | ADORA2BADORA1ADORA2AKDM4EMEN1 | |
| SCHEMBL3466506 | 0.77 | ADORA2B (0.59) | ADORA2BADORA1ADORA2AKDM4EMEN1 | |
| SCHEMBL1944482 | 0.77 | ADORA2B (0.52) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL3466575 | 0.77 | ADORA2B (0.61) | ADORA2BADORA1ADORA2AKDM4EMEN1 | |
| SCHEMBL5685513 | 0.77 | ADORA2B (0.59) | ADORA2BADORA1ADORA2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789053-B1 | METHOD OF WOUND HEALING USING A2B ADENOSINE RECEPTOR ANTAGONISTS | GILEAD SCIENCES INC (US) | 2012-06-13 | — | — | EP | claimed |
| EP-1622908-B1 | XANTHINE DERIVATIVES AS A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-08-06 | — | — | EP | claimed |