Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | RGS4 | P49798 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | RGS8 | P57771 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332943 | 0.94 | LMNA (0.51) | LMNASMN1; SMN2HPGDADORA2BALDH1A1 | |
| SCHEMBL240142 | 0.92 | LMNA (0.51) | LMNASMN1; SMN2HPGDADORA2BALDH1A1 | |
| SCHEMBL2756837 | 0.92 | LMNA (0.51) | LMNASMN1; SMN2HPGDADORA2BALDH1A1 | |
| SCHEMBL2333544 | 0.89 | LMNA (0.52) | LMNASMN1; SMN2HPGDADORA2BALDH1A1 | |
| SCHEMBL1944745 | 0.88 | LMNA (0.53) | LMNASMN1; SMN2HPGDALDH1A1PDE4A | |
| SCHEMBL1945583 | 0.88 | LMNA (0.53) | LMNASMN1; SMN2HPGDALDH1A1PDE4A | |
| SCHEMBL2331175 | 0.86 | LMNA (0.53) | LMNASMN1; SMN2HPGDADORA2BPDE4A | |
| SCHEMBL1546128 | 0.81 | LMNA (0.46) | LMNASMN1; SMN2HPGDADORA2BALDH1A1 | |
| SCHEMBL1945918 | 0.80 | LMNA (0.56) | LMNASMN1; SMN2HPGDADORA2BALDH1A1 | |
| SCHEMBL2543060 | 0.80 | LMNA (0.45) | LMNASMN1; SMN2HPGDADORA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622908-B1 | XANTHINE DERIVATIVES AS A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-08-06 | — | — | EP | disclosed |