SCHEMBL4640099

SCHEMBL4640099

O=C(O)COc1ccc2c(c1)C[C@@H](NC[C@@H](O)c1cccc(Cl)c1)CC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADRB3 P13945 19/20 1.00
ADRB1 P08588 6/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3873178 1.00 ADRB3 (1.00) ADRB3ADRB1
SCHEMBL3873179 1.00 ADRB3 (1.00) ADRB3ADRB1
Hydrochloric Acid SCHEMBL4665229 0.99 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL3878377 0.99 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL4639809 0.99 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL4665231 0.99 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL3878376 0.99 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6133410 0.95 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6133412 0.95 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6604673 0.95 ADRB3 (0.98) ADRB3ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1404641-B1 CRYSTALLINE FORM OF A PHENYLETHANOLAMINE, THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME SANOFI AVENTIS (FR) 2008-08-06 EP claimed
US-6992211-B2 Crystalline form of phenylethanolamine, the preparation thereof and pharmaceutical compositions comprising the same SANOFI-AVENTIS (FR) 2006-01-31 US claimed
US-20040180953-A1 Crystalline form of phenylethanolamine, the preparation thereof and pharmaceutical compositions comprising the same SANOFI-AVENTIS (FR) 2004-09-16 US claimed
EP-0626367-B1 (7S)-7-(1R)-2-(3-chlorophenyl)-2-hydroethylamino-5,6,7,8-tetrahydronaphtalen-2-yloxy acetic acid, their pharmaceutically acceptable salts with a beta-3-adrenergic agonist activity and pharmaceutical compositions containing them SANOFI SA (FR) 1997-04-09 EP claimed
US-5488151-A {(7S)-7-[(2R)-2-(3-chlorophenyl)-2-hydroxyethylamino)-2-hydroxyethylamino]5,} acetic acid and its pharmaceutically acceptable salts SANOFI (FR) 1996-01-30 US claimed
JP-7070013-A None JP disclosed
JP-7070013-A None JP disclosed
EP-3024474-B1 COMPOSITIONS COMPRISING DESMOPRESSIN IN COMBINATION WITH A BETA-3 ADRENERGIC RECEPTOR AGONIST SERENITY PHARMACEUTICALS LLC (US) 2022-01-05 EP disclosed
US-10568927-B2 Methods and compositions comprising desmopressin in combination with a beta-3-adrenergic receptor agonist SERENITY PHARMACEUTICALS LLC (US) 2020-02-25 US disclosed
US-20180289769-A1 METHODS AND COMPOSITIONS COMPRISING DESMOPRESSIN IN COMBINATION WITH A BETA-3-ADRENERGIC RECEPTOR AGONIST FIRST GENERATION CAPITAL INC. (CA) 2018-10-11 US disclosed
US-9814753-B2 Methods and compositions comprising desmopressin in combination with a beta-3-adrenergic receptor agonist SERENITY PHARMACEUTICALS LLC (US) 2017-11-14 US disclosed
US-20160228452-A1 TREATMENT OF METABOLIC DISEASES BY INHIBTION OF HTR2A OR HTR3 KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2016-08-11 US disclosed
US-6992211-B2 Crystalline form of phenylethanolamine, the preparation thereof and pharmaceutical compositions comprising the same SANOFI-AVENTIS (FR) 2006-01-31 US disclosed
US-20040180953-A1 Crystalline form of phenylethanolamine, the preparation thereof and pharmaceutical compositions comprising the same SANOFI-AVENTIS (FR) 2004-09-16 US disclosed
US-6284277-B1 NONPROTEIN SANOFI-SYNTHELABO (FR) 2001-09-04 US disclosed
US-6118025-A Method for preparing optically active α-substituted benzyl alcohols SANOFI-SYNTHELABO (FR) 2000-09-12 US disclosed
US-5488151-A {(7S)-7-[(2R)-2-(3-chlorophenyl)-2-hydroxyethylamino)-2-hydroxyethylamino]5,} acetic acid and its pharmaceutically acceptable salts SANOFI (FR) 1996-01-30 US disclosed
US-5488151-A {(7S)-7-[(2R)-2-(3-chlorophenyl)-2-hydroxyethylamino)-2-hydroxyethylamino]5,} acetic acid and its pharmaceutically acceptable salts SANOFI (FR) 1996-01-30 US disclosed
JP-H0770013-A ((7S)-7-((2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYLAMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YLOXY)ACETIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALT ACTING AS BETA 3-ADRENERGIC AGONISTS, PHARMACEUTICAL COMPOSITION AND LABORATORY REAGENT IN WHICH IT IS PRESENT SANOFI SA 1995-03-14 JP disclosed
JP-H0770013-A ((7S)-7-((2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYLAMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YLOXY)ACETIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALT ACTING AS BETA 3-ADRENERGIC AGONISTS, PHARMACEUTICAL COMPOSITION AND LABORATORY REAGENT IN WHICH IT IS PRESENT SANOFI SA 1995-03-14 JP disclosed