Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640642 | 1.00 | RORC (0.39) | RORCNR1H3NR1I2NR1H2ALDH1A1 | |
| SCHEMBL3625361 | 0.92 | RORC (0.44) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3625359 | 0.92 | RORC (0.44) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3621293 | 0.88 | RORC (0.43) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3621297 | 0.88 | RORC (0.43) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3623615 | 0.83 | RORC (0.45) | RORCNR1H3NR1I2NR1H2ALDH1A1 | |
| SCHEMBL3623612 | 0.83 | RORC (0.45) | RORCNR1H3NR1I2NR1H2ALDH1A1 | |
| SCHEMBL3625401 | 0.81 | RORC (0.46) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3625398 | 0.81 | RORC (0.46) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3625254 | 0.78 | RORC (0.47) | RORCNR1H3NR1I2NR1H2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951676-A2 | LXR MODULATORS | Brystol-Myers Squibb Company (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007050425-A2 | LXR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-03 | — | — | WO | disclosed |