Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 13/20 | 1.00 |
| ▸ | CA12 | O43570 | 8/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.66 |
| ▸ | GLA | P06280 | 5/20 | 0.66 |
| ▸ | GAA | P10253 | 5/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | CASP1 | P29466 | 3/20 | 0.66 |
| ▸ | CASP7 | P55210 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | BCHE | P06276 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15842844 | 0.88 | CA9 (0.78) | CA9CA12KDM4EGLAGAA | |
| Esculetin SCHEMBL6703123 | 0.84 | CA9 (0.85) | CA9CA12KDM4EGLAGAA | |
| Esculetin SCHEMBL8528963 | 0.83 | CA9 (0.82) | CA9CA12KDM4EGLAGAA | |
| Esculetin SCHEMBL24641 | 0.80 | CA9 (1.00) | CA9CA12KDM4EGLAGAA | |
| Esculetin SCHEMBL6867015 | 0.80 | CA9 (1.00) | CA9CA12KDM4EGLAGAA | |
| Esculetin SCHEMBL29569228 | 0.80 | CA9 (1.00) | CA9CA12KDM4EGLAGAA | |
| Esculetin SCHEMBL30120615 | 0.78 | CA9 (0.96) | CA9CA12KDM4EGLAGAA | |
| Esculetin SCHEMBL29163498 | 0.78 | CA9 (0.96) | CA9CA12KDM4EGLAGAA | |
| Esculetin SCHEMBL8708221 | 0.78 | CA9 (0.96) | CA9CA12KDM4EGLAGAA | |
| Esculetin SCHEMBL1736697 | 0.78 | CA9 (0.96) | CA9CA12KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118459444-A | Two hydroxyl-containing 6-dihydropyrazolyl coumarin compounds and preparation method thereof | 河南中烟工业有限责任公司 | 2024-08-09 | — | — | CN | disclosed |
| CN-118459444-A | Two hydroxyl-containing 6-dihydropyrazolyl coumarin compounds and preparation method thereof | 河南中烟工业有限责任公司 | 2024-08-09 | — | — | CN | disclosed |
| EP-1667999-A4 | BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2008-08-06 | — | — | EP | disclosed |
| US-7247646-B2 | Benzopyranone compounds, compositions thereof, and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-24 | — | — | US | disclosed |
| EP-1667999-A1 | BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals LLC (US) | 2006-06-14 | — | — | EP | disclosed |
| US-20050137231-A1 | Benzopyranone compounds, compositions thereof, and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC | 2005-06-23 | — | — | US | disclosed |
| WO-2005028472-A1 | BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137231-A1 | Benzopyranone compounds, compositions thereof, and methods of treatment therewith | ESR1, ESR2, ESRRG | CA9 4036/4885CA12 4374/4885KDM4E 1097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.