SCHEMBL4641479

SCHEMBL4641479

COc1cc(C(C)(C)C)ccc1/C=C/C=C/C(=O)NCc1ccc(CNC(=O)/C=C/C=C/c2ccc(C(C)(C)C)cc2OC)cc1

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LY96 Q9Y6Y9 1/20 0.47
ALDH1A1 P00352 1/20 0.47
POLB P06746 1/20 0.47
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
NPC1 O15118 1/20 0.45
EPHX2 P34913 1/20 0.45
RAB9A P51151 1/20 0.45
NR1H4 Q96RI1 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4641354 0.80 ALDH1A1 (0.46) ALDH1A1MEN1KMT2ANPC1RAB9A
SCHEMBL5573145 0.80 ALDH1A1 (0.46) ALDH1A1MEN1KMT2ANPC1RAB9A
SCHEMBL2949089 0.76 APP (0.51) LY96ALDH1A1MEN1KMT2ANPC1
SCHEMBL2949086 0.76 APP (0.51) LY96ALDH1A1MEN1KMT2ANPC1
SCHEMBL4641556 0.76 KDM4E (0.62) ALDH1A1POLBKMT2A
SCHEMBL4641454 0.75 ALDH1A1 (0.50) ALDH1A1POLBKMT2A
SCHEMBL6793463 0.75 HPGD (0.48) ALDH1A1MEN1KMT2ANPC1RAB9A
SCHEMBL2948511 0.74 ALDH1A1 (0.51) LY96ALDH1A1MEN1KMT2ANPC1
SCHEMBL2948512 0.74 ALDH1A1 (0.51) LY96ALDH1A1MEN1KMT2ANPC1
SCHEMBL2951703 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934924-B1 NOVEL DIAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME KOWA CO (JP) 2008-08-13 EP disclosed
US-6576642-B2 Inhibitors of the production of Ig E antibodies, antiallergens KOWA CO., LTD. (JP) 2003-06-10 US disclosed
US-20010039279-A1 Diamide compounds and compositions containing the same KOWA CO., LTD. (JP) 2001-11-08 US disclosed
US-6297283-B1 EXCELLENT INHIBITORY EFFECT ON THE PRODUCTION OF AN IGE ANTIBODY AND ARE HENCE USEFUL AS ANTIALLERGIC AGENTS KOWA CO., LTD. (JP) 2001-10-02 US disclosed
EP-0934924-A1 NOVEL DIAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME KOWA CO. LTD. (JP) 1999-08-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010039279-A1 Diamide compounds and compositions containing the same HRH4, HRH2, HRH1 LY96 122/4885ALDH1A1 1240/4885POLB 3914/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.