Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 13/20 | 0.78 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.63 |
| ▸ | LTK | P29376 | 1/20 | 0.63 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | EP300 | Q09472 | 2/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.50 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30824997 | 0.95 | IDO1 (0.81) | IDO1CHEK1PIM1LTKLIMK1 | |
| SCHEMBL12599071 | 0.95 | IDO1 (0.81) | IDO1CHEK1PIM1LTKLIMK1 | |
| Ether SCHEMBL6430576 | 0.93 | IDO1 (0.68) | IDO1CHEK1PIM1LTKLIMK1 | |
| SCHEMBL11337260 | 0.90 | IDO1 (0.63) | IDO1CHEK1PIM1LTKLIMK1 | |
| SCHEMBL11399348 | 0.89 | IDO1 (0.61) | IDO1CHEK1PIM1LTKLIMK1 | |
| SCHEMBL6826422 | 0.89 | IDO1 (0.61) | IDO1CHEK1PIM1LTKLIMK1 | |
| SCHEMBL11404368 | 0.89 | IDO1 (0.61) | IDO1CHEK1PIM1LTKLIMK1 | |
| SCHEMBL12599065 | 0.88 | IDO1 (1.00) | IDO1CHEK1PIM1LTKLIMK1 | |
| SCHEMBL11403032 | 0.85 | IDO1 (0.65) | IDO1CHEK1PIM1LTKLIMK1 | |
| SCHEMBL9464309 | 0.84 | IDO1 (0.56) | IDO1CHEK1PIM1LTKLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425261-A2 | METHOD FOR PRODUCING 4-AMINO-1-NAPHTHOL ETHERS | Bayer Chemicals AG (DE) | 2004-06-09 | — | — | EP | claimed |
| WO-2003020686-A2 | METHOD FOR PRODUCING 4-AMINO-1-NAPHTHOL ETHERS | BAYER CHEMICALS AG (DE) | 2003-03-13 | — | — | WO | claimed |
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
| EP-1937243-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007045593-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | APP, BACE1, SNCA | IDO1 2712/4885CHEK1 4299/4885PIM1 3060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.