Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5425468 | 0.85 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL5432128 | 0.82 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4642542 | 0.82 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4646918 | 0.82 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Hydrochloric Acid SCHEMBL5109777 | 0.81 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4648116 | 0.76 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4642488 | 0.74 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4642642 | 0.74 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Hydrochloric Acid SCHEMBL5108285 | 0.72 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4642745 | 0.72 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748043-B1 | Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their préparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2008-08-20 | — | — | EP | disclosed |
| US-7348344-B2 | Polysubstituted 1,1-pyridyloxycyclopropanamine compounds | LES LABORATOIRES SERVIER (FR) | 2008-03-25 | — | — | US | disclosed |
| EP-1748043-A1 | Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their préparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2007-01-31 | — | — | EP | disclosed |