Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.43 |
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777484 | 0.78 | EGFR (0.56) | SIRT2MAPK1NPC1RAB9APLAU | |
| SCHEMBL7968715 | 0.76 | MEN1 (0.66) | ROCK1AURKBGRM4MAPK1NPC1 | |
| SCHEMBL479065 | 0.76 | NPC1 (0.50) | MAPK1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL1795133 | 0.74 | GRM4 (0.53) | GRM4KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL7105114 | 0.72 | NPC1 (0.63) | AURKAAURKBKDM4ENPC1RAB9A | |
| SCHEMBL30073949 | 0.72 | NPC1 (0.63) | AURKAAURKBKDM4ENPC1RAB9A | |
| SCHEMBL23455564 | 0.71 | ROCK1 (0.64) | ROCK1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL28486140 | 0.71 | JAK2 (0.43) | SIRT2NPC1RAB9APKMLMNA | |
| SCHEMBL1881868 | 0.71 | AURKA (0.57) | AURKAAURKBNPC1RAB9ATLR4 | |
| SCHEMBL1881867 | 0.71 | AURKA (0.57) | AURKAAURKBNPC1RAB9ATLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663204-A4 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1663204-A2 | C-KIT MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020921-A2 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |