SCHEMBL4643634

SCHEMBL4643634

COc1ccc(OC(=O)CCl)c(C=O)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.53
RAB9A P51151 1/20 0.53
ALDH1A1 P00352 2/20 0.53
ERN1 O75460 2/20 0.51
MTNR1A P48039 1/20 0.48
MTNR1B P49286 1/20 0.48
TOP2A P11388 1/20 0.48
TRIM24 O15164 1/20 0.47
TYR P14679 1/20 0.47
TRIM33 Q9UPN9 1/20 0.47
JUN P05412 1/20 0.47
NFKB1 P19838 1/20 0.47
TUBB1 Q9H4B7 2/20 0.44
ABCG2 Q9UNQ0 1/20 0.43
TUBB4A P04350 1/20 0.43
TUBB P07437 1/20 0.43
TUBA3C P0DPH7 1/20 0.43
TUBA1B P68363 1/20 0.43
TUBA4A P68366 1/20 0.43
TUBB4B P68371 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4643232 0.89 KDM4E (0.51) KDM4ERAB9AALDH1A1ERN1TOP2A
SCHEMBL4642070 0.87 KDM4E (0.54) KDM4ERAB9AALDH1A1ERN1TRIM24
SCHEMBL4645654 0.85 KDM4E (0.53) KDM4ERAB9AALDH1A1ERN1TRIM24
SCHEMBL4641857 0.85 KDM4E (0.51) KDM4ERAB9AALDH1A1ERN1TOP2A
SCHEMBL4647618 0.84 KDM4E (0.52) KDM4ERAB9AALDH1A1ERN1TRIM24
SCHEMBL1665643 0.83 ALDH1A1 (0.57) KDM4ERAB9AALDH1A1ERN1TRIM24
SCHEMBL4642357 0.83 KDM4E (0.51) KDM4ERAB9AALDH1A1ERN1TRIM24
SCHEMBL16112011 0.83 ALDH1A1 (0.61) KDM4ERAB9AALDH1A1ERN1TRIM24
SCHEMBL4642511 0.82 MRGPRX4 (0.37) KDM4ERAB9ATOP2ACYP2C9
SCHEMBL4643959 0.82 KDM4E (0.50) KDM4ERAB9AALDH1A1ERN1TOP2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 EP disclosed
EP-1487928-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT Jotun AS (NO) 2004-12-22 EP disclosed
WO-2003080747-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2003-10-02 WO disclosed