Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tegaserod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 5/20 | 0.69 |
| ▸ | HTR2C | P28335 | 5/20 | 0.69 |
| ▸ | HTR1D | P28221 | 3/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.69 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.69 |
| ▸ | DRD2 | P14416 | 2/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.69 |
| ▸ | DRD4 | P21917 | 2/20 | 0.69 |
| ▸ | HTR2A | P28223 | 2/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.69 |
| ▸ | DRD3 | P35462 | 2/20 | 0.69 |
| ▸ | HTR2B | P41595 | 2/20 | 0.69 |
| ▸ | HTR3A | P46098 | 2/20 | 0.69 |
| ▸ | HTR5A | P47898 | 2/20 | 0.69 |
| ▸ | HTR6 | P50406 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | DRD5 | P21918 | 1/20 | 0.69 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tegaserod SCHEMBL1042179 | 0.99 | HTR1A (0.70) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL4158807 | 0.99 | HTR1A (0.70) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL3893820 | 0.99 | HTR1A (0.70) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL27215 | 0.99 | HTR1A (0.70) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL20362149 | 0.99 | HTR1A (0.70) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL3229259 | 0.95 | HTR1A (0.63) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL3892146 | 0.95 | HTR1A (0.63) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL4637068 | 0.94 | HTR1A (0.62) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL4636808 | 0.94 | HTR1A (0.62) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL16464 | 0.94 | HTR1A (0.67) | HTR1AHTR2CHTR1DADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956002-A1 | New tegaserod maleate polymorphs and process for their preparation | Chemo Ibérica, S.A. (ES) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007084761-A1 | MALEATE SALT OF TEGASEROD AND CRYSTALLINE FORMS THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-07-26 | — | — | WO | disclosed |