Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4643554 | 1.00 | KDM4E (0.48) | KDM4EMAPTNPC1RAB9AP2RX7 | |
| SCHEMBL3043124 | 1.00 | KDM4E (0.48) | KDM4EMAPTNPC1RAB9AP2RX7 | |
| SCHEMBL3049316 | 0.87 | NPC1 (0.48) | KDM4EMAPTNPC1RAB9AP2RX7 | |
| SCHEMBL3061380 | 0.84 | NPC1 (0.47) | KDM4EMAPTNPC1RAB9AP2RX7 | |
| SCHEMBL4643557 | 0.81 | KDM4E (0.47) | KDM4EMAPTNPC1RAB9AP2RX7 | |
| SCHEMBL3053102 | 0.80 | SLC6A9 (0.48) | NPC1RAB9APOLBTHRBRECQL | |
| SCHEMBL4721249 | 0.79 | SLC6A9 (0.56) | KDM4EMAPTNPC1RAB9ACTSL | |
| SCHEMBL3055700 | 0.71 | SLC6A9 (0.59) | KDM4EMAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL13585912 | 0.71 | POLB (0.53) | KDM4EMAPTNPC1RAB9AP2RX7 | |
| SCHEMBL14476426 | 0.71 | POLB (0.50) | KDM4EMAPTNPC1RAB9AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960360-A1 | AZETIDINE DERIVATIVES AS GLYT1 INHIBITORS | MERCK SHARP & DOHME LTD. (GB) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007060484-A1 | AZETIDINE DERIVATIVES AS GLYT1 INHIBITORS | MERCK SHARP & DOHME LIMITED (GB) | 2007-05-31 | — | — | WO | disclosed |