Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.35 |
| ▸ | GRM6 | O15303 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15219234 | 1.00 | APLNR (0.38) | APLNRFFAR3GRM2GRM3GRM6 | |
| SCHEMBL15338474 | 0.86 | APLNR (0.33) | APLNRFFAR3GRM2GRM3GRM6 | |
| SCHEMBL10254462 | 0.86 | APLNR (0.33) | APLNRFFAR3GRM2GRM3GRM6 | |
| SCHEMBL11757280 | 0.82 | APLNR (0.31) | APLNRGRM2GRM3GRM6 | |
| SCHEMBL7722916 | 0.80 | CYP1A2 (0.37) | APLNRCYP2C19CYP1A2MAPK1TP53 | |
| SCHEMBL4398594 | 0.80 | MAPT (0.37) | APLNRALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL371813 | 0.80 | MAPT (0.37) | APLNRALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL25330082 | 0.75 | — | — | |
| SCHEMBL17479965 | 0.75 | — | — | |
| SCHEMBL20348812 | 0.75 | MAPK1 (0.38) | ALDH1A1MEN1KMT2AKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748043-B1 | Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their préparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007012762-A1 | NOVEL POLYSUBSTITUTED 1,1-PYRIDINYLOXYCYCLOPROPANAMINE COMPOUNDS, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2007-02-01 | — | — | WO | disclosed |
| EP-1748043-A1 | Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their préparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2007-01-31 | — | — | EP | disclosed |
| US-5869737-A | REACTING A MALONIC ACID DERIVATIVE AND A 1,2-DICHLORO COMPOUND WITH AN ALCOHOLATE; CYCLIZATION; SOLVENT EXTRACTION; DISTILLATION | HUELS AKTIENGESELLSCHAFT (DE) | 1999-02-09 | — | — | US | disclosed |