Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12062811 | 0.82 | KMT2A (0.40) | HPGDPTGS2PTGS1KMT2AALDH1A1 | |
| SCHEMBL12896284 | 0.80 | HPGD (0.53) | HPGDMT-CO2PTGS2PTGS1KMT2A | |
| SCHEMBL11130803 | 0.80 | HPGD (0.53) | HPGDMT-CO2PTGS2PTGS1KMT2A | |
| SCHEMBL24395306 | 0.80 | KMT2A (0.39) | HPGDKMT2AALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL3769313 | 0.80 | HPGD (0.43) | HPGDMT-CO2PTGS2PTGS1KMT2A | |
| SCHEMBL1346074 | 0.79 | ESR1 (0.56) | HPGDMT-CO2PTGS2PTGS1KMT2A | |
| SCHEMBL1747458 | 0.79 | ESR1 (0.56) | HPGDMT-CO2PTGS2PTGS1KMT2A | |
| SCHEMBL12424105 | 0.79 | HPGD (0.51) | HPGDMT-CO2PTGS2PTGS1KMT2A | |
| SCHEMBL464581 | 0.79 | PTGS2 (0.57) | HPGDPTGS2PTGS1ALDH1A1CXCR1 | |
| SCHEMBL1345145 | 0.79 | ESR1 (0.56) | HPGDMT-CO2PTGS2PTGS1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065185-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065185-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AADAC, NAT1, PIGO | HPGD 125/4885MT-CO2 3899/4885PTGS2 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.