Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.53 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 2/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4958868 | 0.90 | PTPN1 (0.49) | PTPN1SNRNP200PTGER1HTR1ASLC6A2 | |
| SCHEMBL4646708 | 0.83 | PTPN1 (0.60) | PTPN1PTGER1FFAR4MRGPRX4BRD4 | |
| SCHEMBL4643501 | 0.83 | PTPN1 (0.62) | PTPN1SNRNP200HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4648467 | 0.81 | PTPN1 (0.60) | PTPN1 | |
| SCHEMBL4646366 | 0.80 | PTPN1 (0.61) | PTPN1SNRNP200HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4648546 | 0.80 | PTPN1 (0.57) | PTPN1SNRNP200HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4646906 | 0.79 | PTPN1 (0.53) | PTPN1SNRNP200HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4643306 | 0.79 | PTPN1 (0.53) | PTPN1PTGER1SLC6A4 | |
| SCHEMBL4644677 | 0.78 | PTPN1 (0.52) | PTPN1MRGPRX4BRD4 | |
| SCHEMBL4679242 | 0.77 | PTGER1 (0.35) | PTGER1HTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960377-A1 | l , l , 3-TRI0X0-l , 2 , 5-THIADIAZ0LIDINES AND THEIR USE AS PTP-ASES INHIBITORS | Novartis AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007067614-A1 | l, l, 3-TRI0X0-l, 2, 5-THIADIAZ0LIDINES AND THEIR USE AS PTP-ASES INHIBITORS | NOVARTIS AG (CH) | 2007-06-14 | — | — | WO | disclosed |