SCHEMBL4646915

SCHEMBL4646915

COC(=O)/C=C\C(=O)OC(C(=O)OC(C)=O)c1ccc(OC)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KLK7 P49862 1/20 0.40
MEN1 O00255 2/20 0.38
RAB9A P51151 2/20 0.38
KMT2A Q03164 2/20 0.38
NPSR1 Q6W5P4 1/20 0.38
ACACB O00763 1/20 0.37
GSK3B P49841 1/20 0.37
MTNR1A P48039 1/20 0.37
MTNR1B P49286 1/20 0.37
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36
NPC1 O15118 1/20 0.36
MAPK1 P28482 1/20 0.36
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
LMNA P02545 1/20 0.36
TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4642383 1.00 KLK7 (0.40) KLK7MEN1RAB9AKMT2ANPSR1
SCHEMBL4645412 0.88 TDP1 (0.40) MEN1KMT2AMAPTLMNATDP1
SCHEMBL4644962 0.88 TDP1 (0.40) MEN1KMT2AMAPTLMNATDP1
SCHEMBL4647771 0.86 HCAR2 (0.47) KLK7KMT2AMAPTLMNATDP1
SCHEMBL4645072 0.86 HCAR2 (0.47) KLK7KMT2AMAPTLMNATDP1
SCHEMBL4642392 0.79 SLC2A1 (0.40) MEN1RAB9AKMT2APOLBMAPT
SCHEMBL4647206 0.73 MAPT (0.52) RAB9AMAPTNPC1LMNAALDH1A1
SCHEMBL4645338 0.73 MAPT (0.52) RAB9AMAPTNPC1LMNAALDH1A1
SCHEMBL4641902 0.71 SMN1; SMN2 (0.42) KLK7RAB9AGSK3BNPC1HDAC3
SCHEMBL4641890 0.71 SMN1; SMN2 (0.42) KLK7RAB9AGSK3BNPC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 EP disclosed
EP-1487928-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT Jotun AS (NO) 2004-12-22 EP disclosed
WO-2003080747-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2003-10-02 WO disclosed