Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405985 | 0.81 | GAA (0.49) | GAAALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4648748 | 0.81 | USP2 (0.43) | USP2GAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL19732920 | 0.75 | USP2 (0.63) | USP2GAAALDH1A1KDM4ETP53 | |
| SCHEMBL19732919 | 0.75 | USP2 (0.63) | USP2GAAALDH1A1KDM4ETP53 | |
| SCHEMBL2570938 | 0.75 | USP2 (0.52) | USP2GAAL3MBTL1GRK2ROCK1 | |
| SCHEMBL7660049 | 0.75 | USP2 (0.52) | USP2GAAL3MBTL1GRK2ROCK1 | |
| SCHEMBL19732929 | 0.75 | USP2 (0.52) | USP2GAAL3MBTL1GRK2ROCK1 | |
| SCHEMBL19732961 | 0.74 | USP2 (0.58) | USP2GAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10279779 | 0.74 | USP2 (0.58) | USP2GAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL19732923 | 0.73 | USP2 (0.79) | USP2ALDH1A1KDM4ETP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675834-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1675834-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005037799-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-04-28 | — | — | WO | claimed |