Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.58 |
| ▸ | TSHR | P16473 | 7/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649112 | 0.86 | GAA (0.78) | GAATSHRHTTKMT2ALMNA | |
| SCHEMBL4646686 | 0.83 | GAA (0.55) | GAATSHRHTTKMT2ALMNA | |
| SCHEMBL6405657 | 0.83 | GAA (0.52) | GAATSHRHTTKMT2ALMNA | |
| SCHEMBL4646857 | 0.75 | CREBBP (0.65) | GAATSHRHTTKMT2ALMNA | |
| SCHEMBL4646772 | 0.75 | TSHR (0.59) | GAATSHRHTTKMT2ALMNA | |
| SCHEMBL6408458 | 0.72 | CREBBP (0.62) | GAATSHRHTTKMT2ALMNA | |
| SCHEMBL13753875 | 0.72 | GAA (0.64) | GAATSHRHTTKMT2ALMNA | |
| SCHEMBL4646681 | 0.71 | GAA (0.51) | GAAHSD17B10 | |
| SCHEMBL6408711 | 0.71 | GAA (0.76) | GAATSHRHTTKMT2ALMNA | |
| SCHEMBL6406197 | 0.71 | CREBBP (0.62) | GAATSHRHTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675834-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1675834-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037799-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |