Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405653 | 0.85 | TSHR (0.55) | TSHRGAABLMHTTMAPK10 | |
| SCHEMBL4649112 | 0.77 | GAA (0.78) | TSHRGAABLMHTTMAPK10 | |
| SCHEMBL4648514 | 0.75 | GAA (0.58) | TSHRGAABLMHTTMAPK10 | |
| SCHEMBL4646681 | 0.73 | GAA (0.51) | GAAADORA2B | |
| SCHEMBL4646692 | 0.73 | GAA (0.50) | TSHRGAARAB9AADORA2B | |
| SCHEMBL16323913 | 0.72 | ALDH1A1 (0.81) | TSHRGAAHTTPKMADORA2B | |
| SCHEMBL10113087 | 0.71 | POLB (0.70) | TSHRHTTPKMADORA2B | |
| SCHEMBL3397866 | 0.69 | PKM (0.80) | TSHRGAABLMHTTMAPK10 | |
| SCHEMBL16366979 | 0.69 | RXFP1 (0.80) | — | |
| SCHEMBL16458086 | 0.69 | PKM (0.70) | TSHRGAABLMHTTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675834-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1675834-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037799-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |