Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 13/20 | 0.58 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.38 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622789 | 0.88 | HCAR2 (0.54) | HCAR2HCAR3DAO | |
| SCHEMBL11412506 | 0.74 | HCAR2 (1.00) | HCAR2HCAR3DAOGPR84 | |
| SCHEMBL11231985 | 0.74 | HCAR2 (1.00) | HCAR2HCAR3DAOGPR84 | |
| SCHEMBL11408463 | 0.74 | HCAR2 (1.00) | HCAR2HCAR3DAOGPR84 | |
| SCHEMBL11226614 | 0.74 | HCAR2 (1.00) | HCAR2HCAR3DAOGPR84 | |
| SCHEMBL11403580 | 0.74 | HCAR2 (1.00) | HCAR2HCAR3DAOGPR84 | |
| SCHEMBL11222245 | 0.74 | HCAR2 (1.00) | HCAR2HCAR3DAOGPR84 | |
| Hydrochloric Acid SCHEMBL11397237 | 0.73 | HCAR2 (0.97) | HCAR2HCAR3DAOGPR84 | |
| SCHEMBL7172516 | 0.72 | HCAR2 (1.00) | HCAR2HCAR3DAO | |
| SCHEMBL4621634 | 0.70 | HCAR2 (0.56) | HCAR2HCAR3DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | claimed |