Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28644530 | 0.83 | POLB (0.62) | SMN1; SMN2POLBTP53THRBNPSR1 | |
| SCHEMBL5599416 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2POLBTP53THRBNPSR1 | |
| SCHEMBL4623217 | 0.82 | HCAR2 (0.58) | KDM4EHCAR2 | |
| SCHEMBL13369577 | 0.79 | NPSR1 (0.52) | POLBTP53THRBNPSR1KMT2A | |
| SCHEMBL25312921 | 0.78 | NPSR1 (0.47) | POLBTP53THRBNPSR1KMT2A | |
| SCHEMBL12703567 | 0.78 | HCAR2 (0.67) | SMN1; SMN2POLBTP53THRBKMT2A | |
| SCHEMBL23943148 | 0.78 | NPSR1 (0.47) | POLBTP53THRBNPSR1KMT2A | |
| SCHEMBL1150081 | 0.77 | POLB (0.53) | SMN1; SMN2POLBTP53THRBNPSR1 | |
| SCHEMBL14587608 | 0.76 | NPSR1 (0.50) | POLBTP53THRBNPSR1KMT2A | |
| SCHEMBL4647955 | 0.75 | TP53 (0.53) | SMN1; SMN2POLBTP53THRBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |