Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ASPH | Q12797 | 2/20 | 0.55 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.55 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.55 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648929 | 0.82 | SMN1; SMN2 (0.58) | HCAR2KDM4E | |
| SCHEMBL4646927 | 0.81 | KDM4C (0.52) | HCAR2KDM4CDAO | |
| SCHEMBL5008206 | 0.80 | HCAR2 (0.54) | HCAR2KDM4EKDM6BKDM4DKDM4C | |
| SCHEMBL5599799 | 0.78 | HCAR2 (0.68) | HCAR2 | |
| SCHEMBL4646434 | 0.76 | HCAR2 (0.38) | HCAR2KDM4CDAO | |
| SCHEMBL13827586 | 0.75 | RECQL (0.49) | HCAR2KDM4E | |
| SCHEMBL5008289 | 0.74 | CCNA2 (0.51) | HCAR2KDM4DKDM4C | |
| SCHEMBL12703568 | 0.73 | HCAR2 (1.00) | HCAR2 | |
| SCHEMBL1149172 | 0.72 | HCAR2 (0.73) | HCAR2 | |
| SCHEMBL6761973 | 0.70 | KDM4E (0.57) | HCAR2KDM4EASPHKDM8RIOX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | claimed |