SCHEMBL4649377

SCHEMBL4649377

COc1cc(-c2oc3cc(O)cc(O)c3c(=O)c2OC2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)cc(OC)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
EPHX2 P34913 5/20 0.85
MMP9 P14780 1/20 0.82
P4HB P07237 5/20 0.77
AKR1B1 P15121 4/20 0.77
CA12 O43570 2/20 0.77
CA2 P00918 2/20 0.77
CA4 P22748 2/20 0.77
CA7 P43166 2/20 0.77
ACHE P22303 1/20 0.77
KDM4E B2RXH2 4/20 0.74
GAA P10253 4/20 0.74
POLB P06746 3/20 0.74
MAPT P10636 2/20 0.74
ADRA2C P18825 1/20 0.74
NOX4 Q9NPH5 1/20 0.74
KDM1A O60341 1/20 0.74
SLCO2B1 O94956 1/20 0.74
ALPL P05186 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4649376 1.00 MEN1 (1.00) MEN1KMT2AEPHX2MMP9P4HB
SCHEMBL29962206 1.00 MEN1 (1.00) MEN1KMT2AEPHX2MMP9P4HB
SCHEMBL4650080 1.00 MEN1 (1.00) MEN1KMT2AEPHX2MMP9P4HB
SCHEMBL4650081 1.00 MEN1 (1.00) MEN1KMT2AEPHX2MMP9P4HB
SCHEMBL29887944 0.98 MEN1 (0.96) MEN1KMT2AEPHX2MMP9P4HB
SCHEMBL22023068 0.93 EPHX2 (0.93) MEN1KMT2AEPHX2MMP9P4HB
SCHEMBL25223513 0.92 EPHX2 (1.00) MEN1KMT2AEPHX2MMP9P4HB
SCHEMBL1252883 0.92 EPHX2 (0.90) MEN1KMT2AEPHX2MMP9P4HB
SCHEMBL13926793 0.92 EPHX2 (1.00) MEN1KMT2AEPHX2MMP9P4HB
SCHEMBL31238537 0.92 EPHX2 (1.00) MEN1KMT2AEPHX2MMP9P4HB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
EP-2730431-B1 Rubber composition and tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2017-06-28 EP disclosed
US-20140135433-A1 TIRE WITH RUBBER CONTAINING FLAVONE THE GOODYEAR TIRE & RUBBER COMPANY (US) 2014-05-15 US disclosed
EP-2730431-A1 Rubber composition and tire with rubber containing flavone The Goodyear Tire & Rubber Company (US) 2014-05-14 EP disclosed
EP-1391327-B1 Tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2008-09-03 EP disclosed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US disclosed
EP-1391327-A1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2004-02-25 EP disclosed
WO-2003057210-A1 COMPOSITIONS AND METHODS FOR INCREASING CELL PROLIFERATION COMPRISING A FLAVONOID KIMBERLY-CLARK WORLDWIDE, INC. (US) 2003-07-17 WO disclosed
US-20030125264-A1 Methods For Treating Wounds KIMBERLY-CLARK WORLDWIDE, INC. 2003-07-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030125264-A1 Methods For Treating Wounds FGF2, MMP1, FIBP MEN1 3867/4885KMT2A 4306/4885EPHX2 2982/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.