Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 4/20 | 0.36 |
| ▸ | IL1B | P01584 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.30 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.30 |
| ▸ | KMT5C | Q86Y97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18953567 | 0.74 | CXCR2 (0.46) | CXCR2CXCR1NT5E | |
| SCHEMBL18953662 | 0.73 | CXCR2 (0.33) | CXCR2CXCR1 | |
| SCHEMBL18953399 | 0.73 | CXCR2 (0.56) | CXCR2CXCR1NT5E | |
| SCHEMBL5954222 | 0.72 | CXCR2 (0.59) | CXCR2CXCR1NT5E | |
| SCHEMBL7070580 | 0.72 | MEN1 (0.33) | RIPK1MEN1KMT2AKMT5BKMT5C | |
| SCHEMBL18953569 | 0.72 | CXCR2 (0.42) | CXCR2CXCR1NT5E | |
| SCHEMBL8652429 | 0.71 | HTR5A (0.39) | RIPK1MEN1KMT2AKMT5BKMT5C | |
| SCHEMBL18953537 | 0.71 | CXCR2 (0.58) | CXCR2CXCR1NT5E | |
| SCHEMBL18953672 | 0.71 | CXCR2 (0.44) | CXCR2MEN1KMT2ACXCR1NT5E | |
| SCHEMBL18953483 | 0.71 | NT5E (0.58) | CXCR2MEN1KMT2ACXCR1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631559-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1631559-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005000231-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | claimed |
| EP-1631559-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1631559-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2005000231-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | disclosed |